Quin Hilyer doesn't think Hillary Clinton should be confirmed as Secretary of State, for a variety of reasons. Others suggest the emolument clause of the Constitution or the Clinton's foreign entanglements could create problems during Senator Clinton's confirmation hearing. Maybe, but I doubt it. Most of the potential problems seem basically unrelated to the role of Secretary of State, or have been addressed long ago. Perhaps more relevantly, relationships matter and by all accounts Hillary Clinton has good relationships with her Senate colleagues. I very much doubt her fellow Senators (especially in a large majority Democratic Senate) will play hardball against a colleague.